*{box-sizing:border-box;margin:0;padding:0}
body{font-family:-apple-system,BlinkMacSystemFont,'Segoe UI',sans-serif;background:#f5f6f8;color:#1a1a1a;min-height:100vh;padding:1.5rem}
.page{max-width:1100px;margin:0 auto}
.page-header{display:flex;align-items:center;gap:12px;margin-bottom:1.25rem}
.logo-icon{width:36px;height:36px;background:#1D9E75;border-radius:8px;display:flex;align-items:center;justify-content:center;flex-shrink:0}
.logo-icon i{color:#fff;font-size:18px}
.logo-text{font-size:20px;font-weight:600;color:#1a1a1a}
.logo-sub{font-size:12px;color:#6b7280}
.badge-note{margin-left:auto;font-size:11px;color:#6b7280;background:#fff;border:1px solid #e5e7eb;padding:4px 10px;border-radius:20px}

.app{display:grid;grid-template-columns:260px 1fr;border:1px solid #e5e7eb;border-radius:12px;overflow:hidden;background:#fff;min-height:620px}
.sidebar{background:#f9fafb;border-right:1px solid #e5e7eb;padding:1.25rem;display:flex;flex-direction:column;gap:1rem}
.filter-section{display:flex;flex-direction:column;gap:6px}
.filter-label{font-size:10px;font-weight:600;color:#9ca3af;text-transform:uppercase;letter-spacing:0.06em}
.search-wrap{position:relative}
.search-wrap i{position:absolute;left:9px;top:50%;transform:translateY(-50%);font-size:15px;color:#9ca3af}
#proteinSearch{width:100%;padding:8px 10px 8px 30px;font-size:13px;border-radius:8px;border:1px solid #d1d5db;background:#fff;color:#1a1a1a;outline:none;transition:border-color .15s}
#proteinSearch:focus{border-color:#1D9E75;box-shadow:0 0 0 3px rgba(29,158,117,.12)}
.chip-group{display:flex;flex-wrap:wrap;gap:5px}
.chip{font-size:11px;padding:3px 9px;border-radius:20px;border:1px solid #d1d5db;cursor:pointer;color:#6b7280;background:#fff;transition:all .15s;user-select:none}
.chip:hover{border-color:#1D9E75;color:#1D9E75}
.chip.active{background:#1D9E75;color:#fff;border-color:#1D9E75}
select{width:100%;font-size:12px;padding:6px 8px;border-radius:8px;border:1px solid #d1d5db;background:#fff;color:#1a1a1a;outline:none;cursor:pointer}
select:focus{border-color:#1D9E75}
.stats-row{display:grid;grid-template-columns:1fr 1fr;gap:6px;margin-top:auto;padding-top:0.75rem;border-top:1px solid #e5e7eb}
.stat-box{background:#fff;border:1px solid #e5e7eb;border-radius:8px;padding:8px;text-align:center}
.stat-num{font-size:20px;font-weight:600;color:#1D9E75}
.stat-lbl{font-size:10px;color:#9ca3af;margin-top:1px}

.main{display:flex;flex-direction:column}
.main-header{padding:1rem 1.25rem;border-bottom:1px solid #e5e7eb;display:flex;align-items:center;justify-content:space-between;gap:8px}
.target-name{font-size:15px;font-weight:600;color:#1a1a1a}
.target-desc{font-size:11px;color:#9ca3af;margin-top:1px}
.result-count{font-size:12px;color:#6b7280;white-space:nowrap}
.sort-row{padding:0.6rem 1.25rem;border-bottom:1px solid #e5e7eb;display:flex;align-items:center;gap:10px}
.sort-row label{font-size:12px;color:#6b7280}
.sort-row select{width:auto;font-size:12px;padding:4px 8px}

.table-wrap{overflow-y:auto;flex:1;max-height:500px}
table{width:100%;border-collapse:collapse;font-size:13px}
thead th{position:sticky;top:0;background:#f9fafb;padding:8px 12px;text-align:left;font-size:10px;font-weight:600;color:#9ca3af;letter-spacing:0.05em;text-transform:uppercase;border-bottom:1px solid #e5e7eb;white-space:nowrap;z-index:1}
tbody tr{border-bottom:1px solid #f3f4f6;transition:background .1s;cursor:pointer}
tbody tr:hover{background:#f9fafb}
td{padding:9px 12px;vertical-align:top}
.drug-name{font-weight:600;color:#1a1a1a;font-size:13px}
.drug-id{font-size:10px;color:#9ca3af;font-family:'SF Mono',Menlo,monospace}
.disease-tags{display:flex;flex-wrap:wrap;gap:4px}
.dtag{font-size:10px;padding:2px 7px;border-radius:10px;border:1px solid;white-space:nowrap}
.dtag.cancer{background:#fef2f2;color:#7f1d1d;border-color:#fca5a5}
.dtag.cardio{background:#eff6ff;color:#1e3a5f;border-color:#93c5fd}
.dtag.neuro{background:#f5f3ff;color:#2e1065;border-color:#c4b5fd}
.dtag.metabolic{background:#fffbeb;color:#451a03;border-color:#fbbf24}
.dtag.immuno{background:#f0fdf4;color:#14532d;border-color:#86efac}
.dtag.other{background:#f3f4f6;color:#374151;border-color:#d1d5db}
.moa-pill{font-size:10px;padding:2px 8px;background:#f3f4f6;border:1px solid #e5e7eb;border-radius:10px;color:#4b5563;white-space:nowrap}
.target-mono{font-size:10px;font-family:'SF Mono',Menlo,monospace;color:#4b5563;display:inline-block;margin-right:4px;margin-bottom:2px}
.ev-dot{width:8px;height:8px;border-radius:50%;display:inline-block}
.ev-high{background:#1D9E75}
.ev-med{background:#f59e0b}
.ev-low{background:#ef4444}

.expand-row{display:none;background:#f9fafb}
.expand-row.open{display:table-row}
.expand-td{padding:12px 16px;border-bottom:1px solid #e5e7eb}
.expand-note{font-size:12px;color:#374151;line-height:1.6;margin-bottom:10px}
.expand-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:8px}
.expand-item{background:#fff;border:1px solid #e5e7eb;border-radius:8px;padding:8px}
.expand-item-label{font-size:10px;color:#9ca3af;margin-bottom:2px}
.expand-item-val{font-size:12px;font-weight:600;color:#1a1a1a;font-family:'SF Mono',Menlo,monospace}

.empty{padding:3rem;text-align:center;color:#9ca3af;font-size:13px}
.empty i{font-size:36px;display:block;margin-bottom:8px;color:#d1d5db}

.loading-state{padding:3rem;text-align:center;color:#9ca3af;font-size:13px}
.spinner{width:26px;height:26px;border:2.5px solid #e5e7eb;border-top-color:#1D9E75;border-radius:50%;animation:spin .65s linear infinite;margin:0 auto 12px}
@keyframes spin{to{transform:rotate(360deg)}}

.error-state{padding:3rem;text-align:center;font-size:13px}
.error-state i{font-size:32px;display:block;margin-bottom:8px;color:#ef4444}
#errorMsg{color:#ef4444;font-weight:500;display:block;margin-bottom:4px}
.error-state p{color:#9ca3af}

@media(max-width:700px){
  body{padding:0.75rem}
  .app{grid-template-columns:1fr}
  .sidebar{border-right:none;border-bottom:1px solid #e5e7eb}
  .stats-row{grid-template-columns:repeat(2,1fr)}
  .expand-grid{grid-template-columns:1fr 1fr}
}